diff --git a/CMakeLists.txt b/CMakeLists.txt
index 0af8052..5d5e0ae 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -141,7 +141,7 @@
   endif()
 
   if(CLANG)
-    set(C_CXX_FLAGS "${C_CXX_FLAGS} -Wnewline-eof -fcolor-diagnostics -Wframe-larger-than=25344")
+    set(C_CXX_FLAGS "${C_CXX_FLAGS} -Wnewline-eof -fcolor-diagnostics")
   else()
     # GCC (at least 4.8.4) has a bug where it'll find unreachable free() calls
     # and declare that the code is trying to free a stack pointer.
@@ -158,6 +158,18 @@
     set(C_CXX_FLAGS "${C_CXX_FLAGS} -Wstring-concatenation")
   endif()
 
+  # Clang 12's -Wframe-larger-than reportedly does not work in clang-cl. See
+  # https://crbug.com/boringssl/709. Clang 13 includes the following fix, which
+  # may be related. Speculatively gate on Clang 13. That corresponds to
+  # AppleClang 13.1.6.
+  # https://github.com/llvm/llvm-project/commit/6aaf4fa2885600b0e31042071ad06f78218ab0f2
+  if((CMAKE_C_COMPILER_ID STREQUAL "Clang" AND
+      CMAKE_C_COMPILER_VERSION VERSION_GREATER_EQUAL "13.0.0") OR
+     (CMAKE_C_COMPILER_ID STREQUAL "AppleClang" AND
+      CMAKE_C_COMPILER_VERSION VERSION_GREATER_EQUAL "13.1.6"))
+    set(C_CXX_FLAGS "${C_CXX_FLAGS} -Wframe-larger-than=25344")
+  endif()
+
   if(CLANG OR CMAKE_C_COMPILER_VERSION VERSION_GREATER_EQUAL "7.0.0")
     set(C_CXX_FLAGS "${C_CXX_FLAGS} -Wimplicit-fallthrough")
   endif()